FAP1, polyclonal antibody
Full Product Name
FAP1 polyclonal antibody
Product synonym names
FAPalpha; FOOL; Seprase; FAP; APO1 / CD95 associated phosphatase (Fas); DKFZp686J1497; FAP 1; FAP1; Fas-associated phosphatase 1; Fas-associated protein tyrosine phosphatase 1; HGNC: 9646; hPTPE1; Phosphatase tear; PNP 1; PNP1; Associated protein tyrosine phosphatase 1 Fas; protein tyrosine phosphatase 1E; Non-receptor protein tyrosine phosphatase type 13; Non-receptor protein tyrosine phosphatase type 13; Protein tyrosine phosphatase PTPL1; protein tyrosine phosphatase; non-receptor type 13 (APO-1 / CD95 (Fas) associated phosphatase); PTP BAS; PTP BL; PTP E1; PTP1E; PTPL 1; PTPL1; PTPLE; PTPN 13; PTPN13; Non-receptor tyrosine protein phosphatase type 13
Product gene name
3D structure: ModBase 3D Structure for Q12884
Species reactivity: Human
Specificity: The polyclonal FAP1 antibody detects endogenous levels of FAP1 protein.
Purity / Purification: ProA affinity purified
Shape / Format
Rabbit IgG, 1 mg / ml in PBS with 0.02% sodium azide, 50% glycerol, pH 7.2
Immunogen: recombinant protein
Preparation and storage
- Store at 4 degrees C after defrosting.
- Store aliquots at -20 degrees C or -80 degrees C.
- Avoid repeated freeze/thaw cycles.
Occasionally, small volumes of anti-FAP1 antibody vials may become trapped in the product vial seal during shipping and storage. If necessary, briefly centrifuge the vial in a benchtop centrifuge to dislodge any liquid on the lid of the container. Some products may need to be shipped with dry ice and an additional fee may apply for dry ice.
Related Product Information for anti-FAP1 antibody
FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP works to promote cell proliferation. In embryonic development, FAP works to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of proteolytically inactive N-glycosylated subunits.
The expression of FAP in chondrocyte membranes is positively regulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in patients with osteoarthritis. This expression is co-localized with MMP-1 and MMP-13, as well as with CD44 (v3 and v7 / 8 variants). Mice lacking all copies of the FAP gene have been found to be fertile and have developmental defects or changes in cancer susceptibility.
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