The impact of lymphocyte isolation on induced DNA damage in human blood samples measured by the comet assay.
The comet assay is incessantly utilized in human biomonitoring for the detection of publicity to genotoxic brokers. Peripheral blood samples are most incessantly used and examined both as entire blood or after isolation of lymphocytes (i.e. peripheral blood mononuclear cells, PBMC). To analyze a possible influence of lymphocyte isolation on induced DNA harm in human blood samples, we uncovered blood ex vivo to mutagens with totally different modes of genotoxic motion.
The comet assay was carried out both straight with entire blood on the finish of the publicity interval or with lymphocytes remoted straight after publicity. Along with the really helpful commonplace protocol for lymphocyte isolation, a shortened protocol was established to optimise the isolation process. The outcomes point out that the results of induced DNA strand breaks and alkali-labile websites induced by ionising radiation and alkylants, respectively, are considerably lowered in remoted lymphocytes. In distinction, oxidative DNA base harm (induced by potassium bromate) and secure cumbersome adducts (induced by benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide; BPDE) appear to be much less affected.
Our findings recommend that in vivo-induced DNA harm may also be lowered in remoted lymphocytes compared with the entire blood relying of the sorts of DNA harm induced. As a result of solely small genotoxic results can typically be anticipated in human biomonitoring research with the comet assay after occupational and environmental publicity to genotoxic brokers, any loss is perhaps related and must be averted. The potential for such results and their potential influence on variability of comet assay leads to human biomonitoring must be thought of when performing or evaluating such form of research.
Isolation and Activation of Murine Lymphocytes.
B and T cells, with their extraordinarily various antigen-receptor repertoires, have the flexibility to mount particular immune responses in opposition to virtually any invading pathogen1,2. Understandably, such intricate skills are managed by numerous molecules concerned in numerous mobile processes to make sure well timed and spatially regulated immune responses3. Right here, we describe experimental procedures that permit fast isolation of extremely purified murine lymphocytes utilizing magnetic cell sorting know-how.
The ensuing purified lymphocytes can then be subjected to varied in vitro or in vivo practical assays, such because the dedication of lymphocyte signaling capability upon stimulation by immunoblotting4 and the investigation of proliferative skills by 3H-thymidine incorporation or carboxyfluorescein diacetate succinimidyl ester (CFSE) labeling5-7. Along with evaluating the practical capacities of management and genetically modified lymphocytes, we will additionally decide the T cell stimulatory capability of antigen-presenting cells (APCs) in vivo, as proven in our consultant outcomes utilizing transplanted CFSE-labeled OT-I T cells.
Absolute Configuration of Periplosides C and F and Isolation of Minor Spiro-orthoester Group-Containing Pregnane-type Steroidal Glycosides from Periploca sepium and Their T-Lymphocyte Proliferation Inhibitory Actions.
Additional phytochemical investigation of the foundation bark of Periploca sepium afforded 9 new spiro-orthoester group-containing pregnane-type glycosides termed periplosides O-V and 3-O-formyl-periploside A. The buildings of those glycosides together with absolutely the configuration of the distinctive seven-membered formyl acetal-bridged spiro-orthoester operate and the 4,6-dideoxy-3-O-methyl-Δ3-2-hexosulosyl moiety had been elucidated on the idea of spectroscopic knowledge interpretation and chemical transformation.
Absolutely the configurations of the main compounds periplosides C and F had been established by single-crystal X-ray diffraction evaluation. The remoted compounds had been evaluated for his or her inhibitory actions in opposition to the proliferation of T-lymphocytes. Because of this, periploside C, probably the most ample glycoside containing a spiro-orthoester moiety discovered within the plant, exhibited probably the most favourite selective index worth (SI = 82.5). The size and structure of the saccharide chain within the periplosides had been discovered to affect the inhibitory exercise and the SI worth.
Isolation of T-Cell Receptors Particularly Reactive with Mutated Tumor-Related Antigens from Tumor-Infiltrating Lymphocytes Based mostly on CD137 Expression.
Function: The adoptive switch of lymphocytes genetically modified to specific tumor reactive T-cell receptors (TCR) can mediate tumor regression. Some tumor-infiltrating lymphocytes (TIL) acknowledge somatic mutations expressed solely within the affected person’s tumors, and proof means that clinically efficient TILs goal tumor-specific neoantigens.
Right here we tried to isolate neoantigen-reactive TCRs as a prelude to the therapy of sufferers with autologous T cells genetically modified to specific such TCRs.Experimental Design: Mutations expressed by tumors had been recognized utilizing whole-exome and RNA sequencing. Tandem minigene (TMG) constructs encoding 12-24 mutated gene merchandise had been synthesized, every encoding the mutated amino acid flanked by 12 amino acids of the traditional protein sequence.
TILs had been cultured with autologous dendritic cells (DC) transfected with in vitro transcribed (IVT) mRNAs encoding TMGs and had been evaluated for IFNγ secretion and CD137 expression. Neoantigen-reactive T cells had been enriched from TILs by sorting for CD137+ CD8+ T cells and expanded in vitro Dominant TCR α and β chains had been recognized within the enriched populations utilizing a mixture of 5′ fast amplification of cDNA ends, deep sequencing of genomic DNA, PairSeq evaluation, and single-cell RT-PCR evaluation.
Mouse CD1 Dorsal Root Ganglion Frozen Sections |
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| MF-240 | Zyagen | 10 slides | EUR 266 |
Mouse BLC Dorsal Root Ganglion Frozen Sections |
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| MF-240-BLC | Zyagen | 10 slides | EUR 291 |
Mouse C57 Dorsal Root Ganglion Frozen Sections |
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| MF-240-C57 | Zyagen | 10slides | EUR 291 |
Rat Nodos Ganglion Paraffin Sections* |
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| RP-204 | Zyagen | 10 slides | EUR 393 |
Rat Trigeminal Ganglion Paraffin Sections* |
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| RP-236 | Zyagen | 10 slides | EUR 393 |
Rat WS Nodos Ganglion Paraffin Sections* |
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| RP-204-WS | Zyagen | 10 slides | EUR 393 |
Rat WS Trigeminal Ganglion Paraffin Sections* |
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| RP-236-WS | Zyagen | 10 slides | EUR 393 |
Rat Superior Cervical Ganglion Paraffin Sections* |
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| RP-237 | Zyagen | 10 slides | EUR 393 |
Rat WS Superior Cervical Ganglion Paraffin Sections* |
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| RP-237-WS | Zyagen | 10 slides | EUR 393 |
Rat Dorsal Root Ganglion Neurons |
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| ABC-TC4126 | AcceGen | 1 vial | Ask for price |
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Description: Rat Dorsal Root Ganglion Neurons are suspensions of high quality sensory neurons prepared by standardized methods, and are ready for immediate culture. Each vial of dorsal root ganglia cells contains approximately 200,000 cells in 0.25 ml suspension. |
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Rat Neonatal Dorsal Root Ganglion (Drg) Neurons |
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| ABC-TC5530 | AcceGen | 1 vial | Ask for price |
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Description: Rat Dorsal Root Ganglion Neurons are suspensions of high quality sensory neurons prepared by standardized methods, and are ready for immediate culture.Each vial of dorsal root ganglia cells contains approximately 200,000 cells in 0.25 ml suspension. Cell death will occur during the first few days after plating and debris will be observed. This is normal. After approximately 4 days in culture, the cells will form a neurite network and by the 7th day, debris will be minimal.In the absence of mitotic inhibitors, the neurons tend to cluster (ganglionate) and detach from the substrate. A ganglion is a group of nerve cells forming a nerve center, especially one located outside the brain or spinal cord.Dorsal root ganglion, also called spinal ganglion, is the ganglion of the posterior root of each spinal segmental nerve, containing the cell bodies of the unipolar primary sensory neurons. Dorsal root ganglion cells are pseudounipolar cells. Pseudounipolar cells have 2 axons rather than an axon and dendrite. One axon extends centrally toward the spinal cord; the other axon extends toward the skin or muscle. |
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Cryopreserved Rat Embryonic Dorsal Root Ganglion Neurons |
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| LOR-EDRG-515 | Westburg | each | EUR 1562.97 |
Rat Nodos Ganglion Frozen Sections* |
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| RF-204 | Zyagen | 10 slides | EUR 393 |
Human Skin Paraffin Sections |
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| HP-101 | Zyagen | 10 slides | EUR 228 |
Human Lung Paraffin Sections |
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| HP-601 | Zyagen | 10 slides | EUR 228 |
Human Vein Paraffin Sections |
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| HP-821 | Zyagen | 10 slides | EUR 228 |
Human Nerve Paraffin Sections |
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| HP-261 | Zyagen | 10 slides | EUR 446 |
Human Colon Paraffin Sections |
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| HP-311 | Zyagen | 10 slides | EUR 228 |
Human Liver Paraffin Sections |
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| HP-314 | Zyagen | 10 slides | EUR 228 |
Human Ovary Paraffin Sections |
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| HP-406 | Zyagen | 10 slides | EUR 228 |
Human Aorta Paraffin Sections |
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| HP-807 | Zyagen | 10 slides | EUR 319 |
Human Tongue Paraffin Sections |
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| HP-105 | Zyagen | 10 slides | EUR 228 |
Human Rectum Paraffin Sections |
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| HP-312 | Zyagen | 10 slides | EUR 228 |
Human Testis Paraffin Sections |
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| HP-401 | Zyagen | 10 slides | EUR 228 |
Human Uterus Paraffin Sections |
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| HP-411 | Zyagen | 10 slides | EUR 319 |
Human Larynx Paraffin Sections |
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| HP-603 | Zyagen | 10 slides | EUR 228 |
Human Spleen Paraffin Sections |
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| HP-701 | Zyagen | 10 slides | EUR 228 |
Human Thymus Paraffin Sections |
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| HP-702 | Zyagen | 10slides | EUR 228 |
Human Tonsil Paraffin Sections |
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| HP-707 | Zyagen | 10slides | EUR 228 |
Human Artery Paraffin Sections |
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| HP-810 | Zyagen | 10 slides | EUR 228 |
Human Kidney Paraffin Sections |
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| HP-901 | Zyagen | 10 slides | EUR 228 |
Human Stomach Paraffin Sections |
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| HP-302 | Zyagen | 10 slides | EUR 228 |
Human Adrenal Paraffin Sections |
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| HP-501 | Zyagen | 10 slides | EUR 228 |
Human Thyroid Paraffin Sections |
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| HP-503 | Zyagen | 10 slides | EUR 407 |
Human Trachea Paraffin Sections |
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| HP-602 | Zyagen | 10 slides | EUR 319 |
Human Bladder Paraffin Sections |
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| HP-902 | Zyagen | 10 slides | EUR 228 |
Rat Trigeminal Ganglion Frozen Sections* |
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| RF-236 | Zyagen | 10 slides | EUR 393 |
Human Pancreas Paraffin Sections |
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| HP-313 | Zyagen | 10 slides | EUR 228 |
Human Prostate Paraffin Sections |
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| HP-408 | Zyagen | 10 slides | EUR 228 |
Human Placenta Paraffin Sections |
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| HP-413 | Zyagen | 10 slides | EUR 228 |
Human Esophagus Paraffin Sections |
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| HP-301 | Zyagen | 10 slides | EUR 228 |
Human Pituitary Paraffin Sections |
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| HP-502 | Zyagen | 10 slides | EUR 407 |
Bovine Dorsal Root Ganglia cDNA |
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| BD-240 | Zyagen | 30 reactions | EUR 243 |
Rat WS Nodos Ganglion Frozen Sections* |
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| RF-204-WS | Zyagen | 10 slides | EUR 393 |
Human Gallbladder Paraffin Sections |
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| HP-320 | Zyagen | 10 slides | EUR 228 |
Human Lymph Node Paraffin Sections |
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| HP-703 | Zyagen | 10 slides | EUR 407 |
Rat WS Trigeminal Ganglion Frozen Sections* |
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| RF-236-WS | Zyagen | 10 slides | EUR 393 |
Human Spinal Cord Paraffin Sections |
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| HP-230 | Zyagen | 10 slides | EUR 228 |
DRGX (untagged)-Human dorsal root ganglia homeobox (DRGX) |
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| SC315713 | Origene Technologies GmbH | 10 µg | Ask for price |
Human Heart Atrium Paraffin Sections |
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| HP-802 | Zyagen | 10 slides | EUR 228 |
Human Adipose Tissue Paraffin Sections |
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| HP-103 | Zyagen | 10 slides | EUR 228 |
Human Salivary Gland Paraffin Sections |
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| HP-317 | Zyagen | 10 slides | EUR 228 |
Rat Superior Cervical Ganglion Frozen Sections* |
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| RF-237 | Zyagen | 10 slides | EUR 393 |
Human Seminal Vesicle Paraffin Sections |
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| HP-407 | Zyagen | 10 slides | EUR 319 |
Human Heart Ventricle Paraffin Sections |
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| HP-801 | Zyagen | 10 slides | EUR 228 |
Human Skeletal Muscles Paraffin Sections |
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| HP-102 | Zyagen | 10 slides | EUR 228 |
Human Brain, Cerebellum Paraffin Sections |
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| HP-202 | Zyagen | 10 Slides | EUR 240 |
Recombinant Human Dorsal root ganglia homeobox protein (DRGX) |
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| MBS1167103-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1145 |
Recombinant Human Dorsal root ganglia homeobox protein (DRGX) |
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| MBS1167103-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 780 |
Recombinant Human Dorsal root ganglia homeobox protein (DRGX) |
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| MBS1167103-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 935 |
Recombinant Human Dorsal root ganglia homeobox protein (DRGX) |
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| MBS1167103-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 935 |
Recombinant Human Dorsal root ganglia homeobox protein (DRGX) |
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| MBS1167103-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1095 |
Bovine Dorsal Root Ganglia Total Protein |
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| BT-240 | Zyagen | 0.5mg | EUR 153 |
Human Dorsal root ganglia homeobox protein (DRGX) ELISA Kit |
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| abx511042-96tests | Abbexa | 96 tests | EUR 687.5 |
Human Dorsal root ganglia homeobox protein, DRGX ELISA KIT |
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| ELI-31989h | Lifescience Market | 96 Tests | EUR 988.8 |
Human Dorsal root ganglia homeobox protein, DRGX ELISA Kit |
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| MBS9338443-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Human Dorsal root ganglia homeobox protein, DRGX ELISA Kit |
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| MBS9338443-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Human Dorsal root ganglia homeobox protein, DRGX ELISA Kit |
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| MBS9338443-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Human Dorsal root ganglia homeobox protein, DRGX ELISA Kit |
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| MBS9338443-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
DRGX (GFP-tagged) - Human dorsal root ganglia homeobox (DRGX) |
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| RG222986 | Origene Technologies GmbH | 10 µg | Ask for price |
Rat WS Superior Cervical Ganglion Frozen Sections* |
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| RF-237-WS | Zyagen | 10 slides | EUR 393 |
Rat Eye Paraffin Sections |
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| RP-106 | Zyagen | 10 slides | EUR 266 |
Dog Skin paraffin Sections |
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| DP-101 | Zyagen | 10 slides | EUR 240 |
Dog Lung paraffin Sections |
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| DP-601 | Zyagen | 10 slides | EUR 240 |
Cat Lung Paraffin Sections |
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| FP-601 | Zyagen | 10 slides | EUR 240 |
Pig Lung Paraffin Sections |
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| PP-601 | Zyagen | 10 slides | EUR 240 |
Rat Skin Paraffin Sections |
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| RP-101 | Zyagen | 10 slides | EUR 228 |
Rat Lung Paraffin Sections |
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| RP-601 | Zyagen | 10 slides | EUR 228 |
Human Brain, Cerebral cortex Paraffin Sections |
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| HP-210 | Zyagen | 10 Slides | EUR 240 |
Human Small Intestine, Ileum Paraffin Sections |
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| HP-309 | Zyagen | 10 slides | EUR 228 |
Dog Liver paraffin Sections |
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| DP-314 | Zyagen | 10 slides | EUR 240 |
Dog Ovary paraffin Sections |
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| DP-406 | Zyagen | 10 slides | EUR 240 |
Dog Heart paraffin Sections |
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| DP-801 | Zyagen | 10 slides | EUR 240 |
Cat Liver Paraffin Sections |
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| FP-314 | Zyagen | 10 slides | EUR 240 |
Cat Ovary Paraffin Sections |
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| FP-406 | Zyagen | 10 slides | EUR 240 |
Cat Heart Paraffin Sections |
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| FP-801 | Zyagen | 10 slides | EUR 240 |
Pig Heart Paraffin Sections |
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| PP-801 | Zyagen | 10 slides | EUR 240 |
Pig Aorta Paraffin Sections |
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| PP-807 | Zyagen | 10 slides | EUR 240 |
Pig Colon Paraffin Sections |
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| PP-311 | Zyagen | 10 slides | EUR 240 |
Pig Liver Paraffin Sections |
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| PP-314 | Zyagen | 10 slides | EUR 240 |
Pig Ovary Paraffin Sections |
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| PP-406 | Zyagen | 10 slides | EUR 240 |
Rat Cecum Paraffin Sections |
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| RP-310 | Zyagen | 10 slides | EUR 228 |
Rat Colon Paraffin Sections |
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| RP-311 | Zyagen | 10 slides | EUR 228 |
Rat Liver Paraffin Sections |
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| RP-314 | Zyagen | 10 slides | EUR 228 |
Rat Ovary Paraffin Sections |
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| RP-406 | Zyagen | 10 slides | EUR 228 |
Rat Penis Paraffin Sections |
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| RP-416 | Zyagen | 10 slides | EUR 228 |
Rat Aorta Paraffin Sections |
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| RP-807 | Zyagen | 10 slides | EUR 266 |
DRGX (Myc-DDK-tagged)-Human dorsal root ganglia homeobox (DRGX) |
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| RC222986 | Origene Technologies GmbH | 10 µg | Ask for price |
Dog Tongue paraffin Sections |
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| DP-105 | Zyagen | 10 slides | EUR 240 |
Dog Rectum paraffin Sections |
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| DP-312 | Zyagen | 10 slides | EUR 240 |
Dog Testis paraffin Sections |
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| DP-401 | Zyagen | 10 slides | EUR 240 |
Dog Spleen paraffin Sections |
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| DP-701 | Zyagen | 10 slides | EUR 240 |
Dog Thymus paraffin Sections |
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| DP-702 | Zyagen | 10 slides | EUR 240 |
Dog Kidney paraffin Sections |
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| DP-901 | Zyagen | 10 slides | EUR 240 |
Cat Tongue Paraffin Sections |
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| FP-105 | Zyagen | 10 slides | EUR 240 |
Cat Rectum Paraffin Sections |
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| FP-312 | Zyagen | 10 slides | EUR 240 |
Cat Testis Paraffin Sections |
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| FP-401 | Zyagen | 10 slides | EUR 240 |
Cat Spleen Paraffin Sections |
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| FP-701 | Zyagen | 10 slides | EUR 240 |
Cat Thymus Paraffin Sections |
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| FP-702 | Zyagen | 10 slides | EUR 240 |
Cat Kidney Paraffin Sections |
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| FP-901 | Zyagen | 10 slides | EUR 240 |
Pig Pineal Paraffin Sections |
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| PP-505 | Zyagen | 10 slides | EUR 240 |
Pig Spleen Paraffin Sections |
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| PP-701 | Zyagen | 10 slides | EUR 240 |
Pig Thymus Paraffin Sections |
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| PP-702 | Zyagen | 10 slides | EUR 240 |
Pig Kidney Paraffin Sections |
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| PP-901 | Zyagen | 10 slides | EUR 240 |
Pig Testis Paraffin Sections |
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| PP-401 | Zyagen | 10 slides | EUR 240 |
Pig Uterus Paraffin Sections |
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| PP-411 | Zyagen | 10 slides | EUR 240 |
Rat Tongue Paraffin Sections |
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| RP-105 | Zyagen | 10 slides | EUR 266 |
Rat Rectum Paraffin Sections |
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| RP-312 | Zyagen | 10 slides | EUR 228 |
Rat Testis Paraffin Sections |
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| RP-401 | Zyagen | 10 slides | EUR 228 |
Rat Vagina Paraffin Sections |
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| RP-412 | Zyagen | 10 slides | EUR 228 |
Rat Spleen Paraffin Sections |
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| RP-701 | Zyagen | 10 slides | EUR 228 |
Rat Thymus Paraffin Sections |
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| RP-702 | Zyagen | 10 slides | EUR 228 |
Rat Kidney Paraffin Sections |
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| RP-901 | Zyagen | 10 slides | EUR 228 |
Sheep Skin Paraffin Sections |
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| SP-101 | Zyagen | 10 slides | EUR 240 |
Sheep Lung Paraffin Sections |
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| SP-601 | Zyagen | 10 slides | EUR 240 |
Human Small Intestine, Jejunum Paraffin Sections |
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| HP-308 | Zyagen | 10 slides | EUR 228 |
Dog Stomach paraffin Sections |
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| DP-302 | Zyagen | 10 slides | EUR 240 |
Dog Bladder paraffin Sections |
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| DP-902 | Zyagen | 10 slides | EUR 240 |
Bovine Skin Paraffin Sections |
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| BP-101 | Zyagen | 10 slides | EUR 240 |
Bovine Lung Paraffin Sections |
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| BP-601 | Zyagen | 10 slides | EUR 240 |
Cat Stomach Paraffin Sections |
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| FP-302 | Zyagen | 10 slides | EUR 240 |
Cat Bladder Paraffin Sections |
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| FP-902 | Zyagen | 10 slides | EUR 240 |
Equine Lung Paraffin Sections |
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| EP-601 | Zyagen | 10 slides | EUR 240 |
Pig Adrenal Paraffin Sections |
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| PP-501 | Zyagen | 10 slides | EUR 240 |
Pig Thyroid Paraffin Sections |
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| PP-503 | Zyagen | 10 slides | EUR 240 |
Pig Bladder Paraffin Sections |
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| PP-902 | Zyagen | 10 slides | EUR 240 |
Pig Stomach Paraffin Sections |
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| PP-302 | Zyagen | 10 slides | EUR 240 |
Rat Oviduct Paraffin Sections |
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| RP-410 | Zyagen | 10 slides | EUR 228 |
Rat Adrenal Paraffin Sections |
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| RP-501 | Zyagen | 10 slides | EUR 266 |
Rat Thyroid Paraffin Sections |
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| RP-503 | Zyagen | 10 slides | EUR 266 |
Rat Trachea Paraffin Sections |
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| RP-602 | Zyagen | 10 slides | EUR 266 |
Rat Bladder Paraffin Sections |
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| RP-902 | Zyagen | 10 slides | EUR 228 |
Rat Urethra Paraffin Sections |
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| RP-903 | Zyagen | 10 slides | EUR 228 |
Sheep Colon Paraffin Sections |
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| SP-311 | Zyagen | 10 slides | EUR 240 |
Sheep Liver Paraffin Sections |
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| SP-314 | Zyagen | 10 slides | EUR 240 |
Sheep Ovary Paraffin Sections |
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| SP-406 | Zyagen | 10 slides | EUR 240 |
Sheep Heart Paraffin Sections |
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| SP-801 | Zyagen | 10 slides | EUR 240 |
Sheep Aorta Paraffin Sections |
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| SP-807 | Zyagen | 10 slides | EUR 240 |
Human Small Intestine, Duodenum Paraffin Sections |
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| HP-307 | Zyagen | 10 slides | EUR 228 |
Dog Pancreas paraffin Sections |
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| DP-313 | Zyagen | 10 slides | EUR 240 |
Dog Placenta Paraffin Sections |
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| DP-413 | Zyagen | 10 Slides | EUR 240 |
Hamster Skin Paraffin Sections |
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| AP-101 | Zyagen | 10 slides | EUR 228 |
Hamster Lung Paraffin Sections |
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| AP-601 | Zyagen | 10 slides | EUR 228 |
Bovine Colon Paraffin Sections |
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| BP-311 | Zyagen | 10 slides | EUR 240 |
Bovine Liver Paraffin Sections |
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| BP-314 | Zyagen | 10 slides | EUR 240 |
Bovine Ovary Paraffin Sections |
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| BP-406 | Zyagen | 10 slides | EUR 240 |
Bovine Heart Paraffin Sections |
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| BP-801 | Zyagen | 10 slides | EUR 240 |
Bovine Aorta Paraffin Sections |
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| BP-807 | Zyagen | 10 slides | EUR 240 |
Cat Pancreas Paraffin Sections |
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| FP-313 | Zyagen | 10 slides | EUR 240 |
Equine Brain Paraffin Sections |
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| EP-201 | Zyagen | 10 slides | EUR 240 |
Equine Colon Paraffin Sections |
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| EP-311 | Zyagen | 10 slides | EUR 240 |
Equine Liver Paraffin Sections |
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| EP-314 | Zyagen | 10 slides | EUR 240 |
Equine Heart Paraffin Sections |
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| EP-801 | Zyagen | 10 slides | EUR 240 |
MiniPig Skin Paraffin Sections |
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| NP-101 | Zyagen | 10 slides | EUR 307 |
MiniPig Lung Paraffin Sections |
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| NP-601 | Zyagen | 10 slides | EUR 307 |
Pig Pancreas Paraffin Sections |
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| PP-313 | Zyagen | 10 slides | EUR 240 |
Human PBL retrovirally transduced to specific the TCRs had been evaluated for recognition of related neoantigens.Outcomes: We recognized 27 TCRs from 6 sufferers that acknowledged 14 neoantigens expressed by autologous tumor cells.Conclusions: This technique offers the means to generate T cells expressing neoantigen-reactive TCRs to be used in future adoptive cell switch immunotherapy trials for sufferers with most cancers.